Biografia De Rodolfo Llinas Pdf

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Born16 December 1934 (age 84)
Bogotá, Colombia
ResidenceNew York City, New York, United States
Alma materPontificia Universidad Javeriana and Australian National University
Known forPhysiology of the cerebellum, the thalamus, Thalamocortical dysrhythmia as well as for his pioneering work on the inferior olive, on the squid giant synapse and on human magnetoencephalography (MEG)
AwardsRalph W. Gerard Prize(2018)
Scientific career
FieldsNeuroscience
InstitutionsNYU School of Medicine
Doctoral advisorSir John Eccles
  1. Rodolfo Llins estuvo en la Cumbre Lderes por la Educacin, en Bogot, y present su visin, profundamente crtica, sobre el estado de la educacin en Colombia.SEMANA: Usted lleva 52 aos fuera de Colombia, pero nunca ha faltado a una cumbre como la que se realiz esta semana para hablar de educacin.
  2. Mi querido Doctor Rodolfo Llinas soy su fiel admiradora me llamo Luisa Araujo y me tengo que hacer una tarea donde debo hablar de toda su vida y no sabe lo emosionada que estoy espero que me ayude mucho dandome informacion necesaria para poder hacer mi trabajo es muy importa te oata mi ya que es una nota final y espero hacerlo muy bien y poder exponer su vida profesional de una forma brillante.
  3. Mi querido Doctor Rodolfo Llinas soy su fiel admiradora me llamo Luisa Araujo y me tengo que hacer una tarea donde debo hablar de toda su vida y no sabe lo emosionada que estoy espero que me ayude mucho dandome informacion necesaria para poder hacer mi trabajo es muy importa te oata mi ya que es una nota final y espero hacerlo muy bien y poder exponer su vida profesional de una forma brillante.
Neuropsychology
Mind and brain portal

Rodolfo Llinás Riascos (Bogotá, Colombia 16 December 1934) is a Colombian-Americanneuroscientist. He is currently the Thomas and Suzanne Murphy Professor of Neuroscience and Chairman Emeritus of the department of Physiology & Neuroscience at the NYU School of Medicine. Llinás has published over 800 scientific articles.[1]

  • 9Selected bibliography
  • 11External links

Early life[edit]

Llinás was born in Bogotá, Colombia. He is the son of Jorge Enrique Llinas (a surgeon) and Bertha Riascos. He was motivated to study the brain by watching his grandfather Pablo Llinás Olarte working as a neuropsychiatrist. Llinás is an atheist[citation needed] and describes himself as a logical positivist.[1]

Biografia De Rodolfo Llinas Pdf

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Education and early research[edit]

Llinás went to the Gimnasio Moderno school in Bogotá and graduated as a medical doctor from the Pontifical Xavierian University in 1959.[2]Bashing grounds hacked photos. During his medical studies he had the opportunity to travel to Europe and there he met several researchers in Spain, France and finally Switzerland, where he participated in neurophysiology experiments with Dr. Walter Rudolf Hess, Nobel Prize in Physiology, Medicine, professor and director of the Department of the Institute of Physiology of the University of Zurich. Additionally, while studying medicine he made a theoretical thesis on the visual system under the tuition of neurosurgeon and neurophysiologist Fernando Rosas and the mathematician Carlo Federici at the National University of Colombia.[3] He received his PhD in 1965 from the Australian National University working under Sir John Eccles.[2]

Personal life[edit]

By graduation in Australia he was very interested in the biological basis of the mind. During this time he met his future wife who was studying philosophy. His two sons are also physicians and his wife is an australian philosopher of mind.[3]Llinás was a scientific advisor during the establishment of an interactive science museum located in Bogotá, Colombia called Maloka Museum. Recently, Llinás has donated a T-Rex skeleton to the museum and helped to design a model of the nervous system for the dinosaur fossils.[4][5]

Work[edit]

He has studied the electrophysiology of single neurons in the cerebellum, the thalamus, the cerebral cortex, the entorhinal cortex, the hippocampus, the vestibular system, the inferior olive and the spinal cord. He has studied synaptic transmitter release in the squid giant synapse. He has studied human brain function using magnetoencephalography (MEG) on the basis of which he introduced the concept of Thalamocortical dysrhythmia.[6]

Career[edit]

Llinás has occupied a number of positions.[7]

  • Research fellow, Massachusetts General Hosp.-Harvard University, 1960–61
  • National Institutes of Health research fellow in physiology, University of Minnesota, Minneapolis, 1961–63
  • Associate professor, University Minnesota, Minneapolis, 1965–66
  • Associate member, American Medical Association Institute Biomed. Research, Chicago, 1966–68
  • Member, American Medical Association Institute Biomed. Research, Chicago, 1970
  • Head neurobiology unit, American Medical Association Institute Biomed. Research, Chicago, 1967–70
  • Associate professor neurology and psychiatry, Northwestern University, 1967–71
  • Guest professor physiology, Wayne State University, 1967–74
  • Professorial lecturer pharmacology, University Ill.-Chgo., 1967–68
  • Clinical professor, University Ill.-Chgo., 1968–72
  • Professor physiology, head neurobiology div., University of Iowa, 1970–76
  • Prof., chairman physiology and biophysics, New York University, New York City, 1976—2011
  • Thomas and Suzanne Murphy professor neuroscience., New York University, 1985—
  • University Professor, Department of Neuroscience and Physiology., New York University, 2011—

Contributions[edit]

  • Discovery of dendritic inhibition in central neurons (at the mammalian motoneuron).[8][9]
  • The functional organization of the cerebellar cortex neuronal circuits.[10]
  • Defining cerebellar function from an evolutionary perspective.[11]
  • First description of electrical coupling in the mammalian CNS (mesencephalic trigeminal nucleus).[12]
  • First determination of presynaptic calcium current, under voltage clamp, at the squid giant synapse.[13][14]
  • Discovery that vertebrate neurons (cerebellar Purkinje cell) can generate calcium-dependent spikes.[15][16]
  • Proposal and Organization of NASA Neurolab Project that flew on April 17, 1998, Space Shuttle Columbia.[17]
  • Discovery of the P-type calcium channel in the Purkinje cells.[15]
  • Discovery of low threshold spikes generated by low voltage activated calcium conductaces (presently known as due to T-type calcium channel) in inferior olive and thalamus neurons.[18][19]
  • A tensor network model of the transformation of sensory space-time coordinates into motor coordinates by the cerebellum.[20]
  • Asserting the law of no interchangeability of neurons, which it is known as Llinás' law.[21]
  • Direct demonstration of calcium concentration microdomains at the presynaptic active zone.[22]
  • Utilization of magnetoencephalography in clinical research.[23]
  • Discovery of subthreshold membrane potential oscillations in the inferior olive, thalamus and entorhinal cortex.[24][25]
  • The discovery of Thalamocortical dysrhythmia.[6]
  • Artificial olivo-cerebellar motor control system as part of the project BAUV (Undersea Vehicle) of the US Navy developed by P. Bandyopadhyay.[26][27]

Memberships and Honors[edit]

Biografia De Rodolfo Llinas Pdf Pdf

Llinás is a member of the United States National Academy of Sciences (1986), the American Academy of Arts and Sciences (1996), American Philosophical Society (1996), the Real Academia Nacional de Medicina (Spain) (1996) and the French Academy of Science (2002). Dr. Llinás has received honorary degrees from the following universities:

  • Universidad de Salamanca (Spain) (1985)
  • Universitat Autonoma de Barcelona (Spain) (1993)
  • National University of Colombia (1994)
  • Universidad Complutense, Madrid, Spain (1997)
  • Los Andes University (Colombia), Bogotá, Colombia, (1998)
  • Toyama University, Toyama, Japan (2005)
  • University of Pavia, Pavia, Italy (2006)

Dr. Llinás has received the following awards:

  • UNESCO Albert Einstein medal (1991)
  • Order of Boyaca Awarded President of Colombia for exceptional service to Colombia (1992)
  • Bernard Katz Award Biohysical Society, Washington USA (2012)[2]
  • Gold Medal of CSIC [es], Spanish National Research Council, Madrid, Spain (2012)[3]
  • Cajal Diploma given by Queen Sofia of Spain Madrid, Spain (2013)[4]
  • Ragnar Granit Lecture and Award, Nobel Institute, Stockholm, Sweden (2013)
  • Castilla del Pino Lecture and Award Cordoba, Spain (2015)[5]
  • Nansen Neuroscience Lecture and award Norwegian Academy of Science, Oslo, Norway (2016)[6]
  • Scholar of the Year Australian National University, Canberra, Australia (2016)[7]
  • Ralph W. Gerard Prize in NeuroscienceSociety for Neuroscience, (2018) [8]

He was the chairman of NASA/Neurolab Science Working Group, in 2011 received University Professor Distinction from New York University [9] and in 2013, the NYU Neuroscience Institute created the Annual Rodolfo Llinás Lecture Series in recognition of his contributions to the field of neuroscience.[28]

Filmography[edit]

  • Llinas, el cerebro y el universo. Documentary film, by Gonzalo Argandoña, Cabala Producción Audiovisual, (2018) RTVCplay [10]

Selected bibliography[edit]

Books[edit]

  • Hubbard, J.I., Llinás, R. and Quastel, D.M.J. Electrophysiological Analysis of Synaptic Transmission. London: Edward Arnold Publishers 1969.
  • Llinás, R. Editor. Neurobiology of Cerebellar Evolution and Development. (Chicago: Am. Med. Association, 1969)
  • Precht, W., Llinás, R. (eds.): Frog Neurobiology: a handbook. (Berlin: Springer-Verlag, 1976). link.springer.com/10.1007/978-3-642-66316-1ISBN978-3-642-66318-5
  • Steriade, M., Jones, E., y Llinás, R (Eds.): Thalamic Oscillations and Signaling. The Neurosciences Institute Publications Series. (John Wiley & Sons, 1990). ISBN0-471-51508-6
  • Llinás, R. y Sotelo, C (eds.): The Cerebellum Revisited. (Nueva York: Springer-Verlag, 1992). link.springer.com/10.1007/978-1-4612-2840-0ISBN978-1-4612-7691-3
  • Buzsaki, G., Llinas, R., Singer, W., Berthoz, A. , Christen, Y. (eds.): Temporal Coding in the Brain. (Nueva York: Springer-Verlag, 1994). link.springer.com/10.1007/978-3-642-85148-3ISBN978-3-642-85150-6
  • Latorre, R., López-Barneo, J., Bezanilla, F., Llinás, R. (Eds) Biofísica y fisiología celular. (Universidad de Sevilla, España, 1996). ISBN84-472-0339-5
  • Llinás, Rodolfo R. and Churchland, Patricia S. Mind-Brain Continuum: Sensory Processes The MIT Press (September 9, 1996) ISBN0-262-12198-0
  • Llinás, Rodolfo R. The Squid Giant Synapse : A Model for Chemical Transmission Oxford University Press, USA (December 15, 1999) ISBN0-19-511652-6
  • Llinás, Rodolfo. El reto: Educación, Ciencia y Tecnología. Tercer Mundo Editores, (2000) ISBN978-958-601-887-6
  • Llinás, R. I of the vortex: from neurons to self (MIT Press, Cambridge, MA. 2001). ISBN0-262-62163-0

Book chapters[edit]

  • Llinas R, Rivary U. Perception as an oneiric-like state modulated by the senses. Chapter 6. In: Koch C. Large-scale neuronal theories of the brain. Bradford Book. (1994). ISBN9780262111836
  • Llinas RR., Walton KD. Cerebellum. Chapter 7. In: Shepherd GM. The synaptic organization of the brain. 4th Ed. New York: Oxford University Press. (1998) ISBN0195118243
  • Llinas RR., Walton KD., Lang EJ. Cerebellum. Chapter 7. In: Shepherd GM. The synaptic organization of the brain. 5th Ed. Oxford University Press. (2004) ISBN0195159551
  • Llinas, R. R. Neuroscientific basis of consciousness and dreaming. Chapter 3.6. In: Kaplan and Sadock's Comprehensive textbook of psychiatry. Philadelphia: Lippincott Williams & Wilkins. 8th ed. (2005).
  • Llinás, R. Electrophysiology of the Cerebellar Networks. Comprehensive Physiology (2011). Supplement 2. Handbook of Physiology, The Nervous System, Motor Control. doi:10.1002/cphy.cp010217ISBN9780470650714
  • Llinas RR., Walton K. Central pain: a thalamic deafferentation generating thalamocortical dysrhythmia. Chapter 4. In: Saab CY. Chronic pain and brain abnormalities. Academic Press-Elsevier (2014). ISBN9780123983893
  • Llinas, RR. Oscillation in the inferior olive neurons: Functional implication. Chapter 39. pp. 293–298. In: Essentials of Cerebellum and Cerebellar Disorders: A Primer for Graduate Students. Springer (2016) ISBN978-3-319-24551-5
  • Llinas, R. R. Consciousness and Dreaming from a Pathophysiological Perspective: The Thalamocortical Dysrhythmia Syndrome. Chapter 3.5. In: Kaplan and Sadock's Comprehensive textbook of psychiatry. Philadelphia: Lippincott Williams & Wilkins. 10th ed. (2017). ISBN978-1-4511-0047-1

Selected review articles[edit]

  • Llinás RR. The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. Science. 1988 Dec 23;242(4886):1654-64.
  • Llinás RR, Sugimori M, Cherksey B. Voltage-dependent calcium conductance in mammalian neurons. The P channel. Ann N Y Acad Sci. 1989;560:103-11.
  • Llinás RR. Depolarization release coupling: an overview. Ann N Y Acad Sci. 1991;635:3-17.
  • Llinás RR, Paré D. Of dreaming and wakefulness. Neuroscience. 1991;44(3):521-35.
  • Llinás R, Ribary U. Consciousness and the brain. The thalamocortical dialogue in health and disease. Ann N Y Acad Sci. 2001 Apr;929:166-75. doi:10.1111/j.1749-6632.2001.tb05715.x
  • Llinás, Rodolfo R., and Steriade, Mircea. Bursting of thalamic neurons and states of vigilance. Invited Review J. Neurophysiol., 95:3297-3308, 2006. doi:10.1152/jn.00166.2006
  • Roy S, Llinás R. Dynamic geometry, brain function modeling, and consciousness. Prog Brain Res. 2008;168:133-44. doi:10.1016/S0079-6123(07)68011-X
  • Llinás RR. Cerebellar motor learning versus cerebellar motor timing: the climbing fibre story. J Physiol. 2011 Jul 15;589(Pt 14):3423-32. doi:10.1113/jphysiol.2011.207464
  • Buzsáki G, Llinás R. Space and time in the brain. Science. 2017 Oct 27;358(6362):482-485. doi:10.1126/science.aan8869

References[edit]

  1. ^P. (2016). Rodolfo R. Llinas - Can Science Talk God? Retrieved August 26, 2016, from https://www.closertotruth.com/series/can-science-talk-god
  2. ^ abSquire, Larry R (2006). The history of neuroscience in autobiography. New York, New York: Elsevier. p. 413. ISBN978-0-12-370514-3.
  3. ^ abCorrea, Pablo (2017). Rodolfo Llinás. La pregunta difícil (in Spanish). Aguilar. ISBN9789585425408.
  4. ^Tiempo, Casa Editorial El (2018-07-24). 'Maloka se reinventa y estrena atracción: un tiranosaurio rex'. El Tiempo (in Spanish). Retrieved 2019-05-22.
  5. ^EL TIEMPO (2018-07-26), Rodolfo Llinás regaló un T Rex a Maloka EL TIEMPO, retrieved 2019-05-22
  6. ^ abLlinás R, Ribary U, Jeanmonod D, Kronberg E, Mitra P (1999). 'Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography'. Proc. Natl. Acad. Sci. U.S.A. 96 (26): 15222–7. doi:10.1073/pnas.96.26.15222. PMC24801. PMID10611366.
  7. ^Perruso, Alison, ed. (2016) [April 2016]. Who's Who in Science and Engineering 2016-2017. New Providence, New Jersey: Marquis Who's Who, 2016. ISBN978-0-8379-5772-2.
  8. ^Llinas, R; Terzuolo CA (1964). 'Mechanisms of supraspinal actions upon spinal cord activities. Reticular inhibitory mechanisms on alpha-extensor motoneurons'. The Journal of Neurophysiology. 27 (4): 579–491. doi:10.1152/jn.1964.27.4.579. PMID14194959.
  9. ^Llinas, R; Terzuolo CA (1965). 'Mechanisms of supraspinal actions upon spinal cord activities. Reticular inhibitory mechanisms upon flexor motoneurons'. The Journal of Neurophysiology. 28 (2): 413–422. doi:10.1152/jn.1965.28.2.413. PMID14283063.
  10. ^Llinás, Rodolfo; Walton, Kerry D; Lang, Eric J (2004) [1st pub. 1974]. 'Chapter 7: Cerebellum'. In Shepherd, Gordon M (ed.). The synaptic organization of the brain. New York, New York: Oxford University press. pp. 271–310. ISBN978-0-19-515955-4.
  11. ^Llinas, RR (1969). 'Functional aspects of interneuronal evolution in the cerebellar cortex'. UCLA Forum Med Sci. 11: 329–48. PMID5397400.
  12. ^Baker, R.; Llinás, R. (1971-01-01). 'Electrotonic coupling between neurones in the rat mesencephalic nucleus'. The Journal of Physiology. 212 (1): 45–63. doi:10.1113/jphysiol.1971.sp009309. ISSN0022-3751. PMC1395705. PMID5545184.
  13. ^Llinás, R.; Steinberg, I. Z.; Walton, K. (1976-08-01). 'Presynaptic calcium currents and their relation to synaptic transmission: voltage clamp study in squid giant synapse and theoretical model for the calcium gate'. Proceedings of the National Academy of Sciences of the United States of America. 73 (8): 2918–2922. doi:10.1073/pnas.73.8.2918. ISSN0027-8424. PMC430802. PMID183215.
  14. ^Llinás, R.; Steinberg, I. Z.; Walton, K. (1980-09-01). 'Transmission in the squid giant synapse: a model based on voltage clamp studies'. Journal de Physiologie. 76 (5): 413–418. ISSN0021-7948. PMID6256531.
  15. ^ abLlinas, R; Sugimori (1980). 'Electrophysiological Properties of in Vitro Purkinje Cell Somata in Mammalian Cerebellar Slices'. The Journal of Physiology. 305: 171–195. doi:10.1113/jphysiol.1980.sp013357.
  16. ^Llinás, R.; Sugimori, M. (1980-08-01). 'Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices'. The Journal of Physiology. 305: 197–213. doi:10.1113/jphysiol.1980.sp013358. ISSN0022-3751. PMC1282967. PMID7441553.
  17. ^Buckey, Jay C. (2003). Neurolab Spacelab Mission: Neuroscience Research in Space. Houston, Texas: NASA. ISBN978-0-9725339-0-4.
  18. ^Llinás, R.; Yarom, Y. (June 1981). 'Electrophysiology of mammalian inferior olivary neurones in vitro. Different types of voltage-dependent ionic conductances'. The Journal of Physiology. 315: 549–567. doi:10.1113/jphysiol.1981.sp013763. ISSN0022-3751. PMC1249398. PMID6273544.
  19. ^Llinás, R.; Yarom, Y. (June 1981). 'Properties and distribution of ionic conductances generating electroresponsiveness of mammalian inferior olivary neurones in vitro'. The Journal of Physiology. 315: 569–584. doi:10.1113/jphysiol.1981.sp013764. ISSN0022-3751. PMC1249399. PMID7310722.
  20. ^Roy, Sisir; Llinás, Rodolfo (2007). Models of Brain and Mind - Physical, Computational and Psychological Approaches. Progress in Brain Research. 168. pp. 133–144. doi:10.1016/s0079-6123(07)68011-x. ISBN9780444530509. PMID18166391.
  21. ^Llinás, Rodolfo (1990). «Intrinsic Electrical Properties of Mammalian Neurons and CNS Function». Fidia Research Foundation Neuroscience Award Lectures, 1988-1989 (Raven Press) 4: p. 175.
  22. ^Llinas, R; Sugimori, M; Silver, R. (1 May 1992). 'Microdomains of high calcium concentration in a presynaptic terminal'. Science. 256 (5057): 677–679. doi:10.1126/science.1350109. PMID1350109.
  23. ^Rezai, A. R.; Hund, M.; Kronberg, E.; Deletis, V.; Zonenshayn, M.; Cappell, J.; Ribary, U.; Llinás, R.; Kelly, P. J. (1995). 'Introduction of magnetoencephalography to stereotactic techniques'. Stereotactic and Functional Neurosurgery. 65 (1–4): 37–41. doi:10.1159/000098894. ISSN1011-6125. PMID8916327.
  24. ^Llinas R., Yarom Y. (1986). 'Oscillatory properties of guinea-pig inferior olivary neurones and their pharmacological modulation: an in vitro study'. J. Physiol. 376: 163–182. doi:10.1113/jphysiol.1986.sp016147. PMC1182792. PMID3795074.
  25. ^Alonso A., Llinas R. (1989). 'Subthreshold Na+-dependent theta-like rhythmicity in entorhinal cortex layer II stellate cells'. Nature. 342 (6246): 175–177. doi:10.1038/342175a0. PMID2812013.
  26. ^Llinas, R. R.; Leznik, E.; Makarenko, V. I. (July 2004). 'The olivo-cerebellar circuit as a universal motor control system'. IEEE Journal of Oceanic Engineering. 29 (3): 631–639. doi:10.1109/joe.2004.833212. ISSN0364-9059.
  27. ^Bandyopadhyay, Promode R. (2016). '11. Highly Maneuverable Biorobotic Underwater Vehicles'. In Dhanak, MR (ed.). Springer Handbook of Ocean Engineering SpringerLink. Springer International Publishing. p. 1287. doi:10.1007/978-3-319-16649-0. ISBN978-3-319-16648-3.
  28. ^'Neuroscience Institute Events'.

External links[edit]

Wikimedia Commons has media related to Rodolfo Llinás.
  • 'List of Articles on Google Scholar'. Google Scholar. 2016. Retrieved 2 June 2016.

Newspaper articles[edit]

  • Estrella de la sabiduría en la Universidad Nacional Tribute at National University of Colombia
  • Enter the 'I' of the VortexThe Science Network interview with Rodolfo Llinás
  • In a Host of Ailments, Seeing a Brain Out of Rhythm The New York Times December 8, 2008
  • New Way Of Looking At Diseases Of the Brain The New York Times October 26, 1999
  • Listening to the Conversation of Neurons The New York Times May 27, 1997
  • New York Times announcement of election to the [National Academy of Sciences]

Rodolfo Llinas Wiki

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